CSIL is supporting The Italian Research Council (CNR) to evaluate the socio-economic impact and a cost-benefit analysis of a European Research Infrastructure for Heritage Science, in the framework of the H2020-funded project E-RIHS. The European Research Infrastructure for Heritage Science is a distributed Research Infrastructure (RI) including the Central Hub and a large number of research facilities focused on the preservation of the world’s heritage by providing cross-cutting edge researchers, knowledge, capabilities and infrastructures. It is a publicly funded RI, and it is, therefore, crucial to estimate the return on investment and the ability to generate an economic and social value per countries involved. CSIL’s analysis will assess benefits at different timeframes, geographic scales and in different domains. Also, special attention is put to the impact on preventive conservation, tourism and cultural and creative industries, as well as E-RIHS contribution to the knowledge, conservation, valorisation and management of heritage.